Search results for "Cytokine Expression Profile"

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Cytokine expression profile in idiopathic inflammatory myopathies.

1996

Cytokines have been shown to be potent inducers of major histocompatibility complexes (MHC) class I and II as well as of cell adhesion molecules in muscle tissue cultures, indicating that cytokines may play a role in mediating muscle fiber damage in inflammatory myopathies. We found in 21 cases of autoimmune myositis various amounts of inflammatory cells expressing interleukin (IL)-1 alpha and -beta, IL-2, IL-4, tumor necrosis factor (TNF) -alpha and -beta, and interferon (IFN)-gamma and its receptor. Muscle fibers displayed enhanced expression of IL-1 alpha and -beta, IL-2, and TNF-alpha. Upregulation of cytokines was strongest at sites of cellular infiltration typical for the respective m…

medicine.medical_treatmentMuscle Fibers SkeletalInflammationCytokine Expression ProfileBiologyMuscular DystrophiesPathology and Forensic MedicineCellular and Molecular NeuroscienceInterferonmedicineCytotoxic T cellHumansInterleukin 4InflammationInterleukinGeneral MedicineImmunohistochemistryPolymyositisCytokineNeurologyImmunologyCytokinesTumor necrosis factor alphaNeurology (clinical)medicine.symptommedicine.drugJournal of neuropathology and experimental neurology
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